검색어 : 통합검색[Symons Julian]
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101
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Proton relative biological effectiveness (RBE) for survival in mice after thoracic irradiation with fractionated doses
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Gueulette, John;
Bö
hm, Lothar;
Slabbert, Jacobus P;
De Coster, Blanche M;
Rutherfoord, Gerald S;
Ruifrok, Arnout;
Octave-Prignot, Michelle;
Binns, Peter J;
Schreuder, A.Nicholaas;
Symons, Julian E;
Scalliet, Pierre;
Jones, Dan T.L;
;
(International journal of radiation oncology, biology, physics,
v.47,
2000,
pp.1051-1058)
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102
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TOP-358-YI Non-HAP CAM-A ALG-006746 and ALG-006780 induce rapid HBsAg reductions in AAV-HBV mice and have favorable pharmacokinetic profiles
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Vanrusselt, Hannah;
Verheyen, Jordi;
Gupta, Kusum;
Degrauwe, Lars;
Liu, Cheng;
Sanchez, Abel Acosta;
Bollier, Mé
lanie;
Nshimyumuremyi, Jean-Boris;
Verburgh, Benjamin;
Peter, Clovis;
Zhang, Qingling;
Blatt, Lawrence;
Beigelman, Leonid;
Symons, Julian;
Chanda, Sushmita;
Smith, David;
Jekle, Andreas;
Vendeville, Sandrine;
McGowan, David;
Debing, Yannick;
;
(Journal of hepatology : the journal of the European Association for the Study of the Liver,
v.80,
2024,
pp.S728)
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103
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Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models
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Jekle, Andreas;
Thatikonda, Santosh Kumar;
Jaisinghani, Ruchika;
Ren, Suping;
Kinkade, April;
Stevens, Sarah K.;
Stoycheva, Antitsa;
Rajwanshi, Vivek K.;
Williams, Caroline;
Deval, Jerome;
Mukherjee, Sucheta;
Zhang, Qingling;
Chanda, Sushmita;
Smith, David B.;
Blatt, Lawrence M.;
Symons, Julian A.;
Gonzalvez, Francois;
Beigelman, Leonid;
Aligos Therapeutics, Inc., South San Francisco, CA 94080, USA;
Aligos Therapeutics, Inc., South San Francisco, CA 94080, USA;
Aligos Therapeutics, Inc., South San Francisco, CA 94080, USA;
Aligos Therapeutics, Inc., South San Francisco, CA 94080, USA;
Aligos Therapeutics, Inc., South San Francisco, CA 94080, USA;
Aligos Therapeutics, Inc., South San Francisco, CA 94080, USA;
Aligos Therapeutics, Inc., South San Francisco, CA 94080, USA;
Aligos Therapeutics, Inc., South San Francisco, CA 94080, USA;
Aligos Therapeutics, Inc., South San Francisco, CA 94080, USA;
Aligos Therapeutics, Inc., South San Francisco, CA 94080, USA;
Aligos Therapeutics, Inc., South San Francisco, CA 94080, USA;
Aligos Therapeutics, Inc., South San Francisco, CA 94080, USA;
Aligos Therapeutics, Inc., South San Francisco, CA 94080, USA;
Aligos Therapeutics, Inc., South San Francisco, CA 94080, USA;
Aligos Therapeutics, Inc., South San Francisco, CA 94080, USA;
Aligos Therapeutics, Inc., South San Fra;
(International journal of molecular sciences,
v.24,
2023,
pp.16274)
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104
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THU-198 In vitro and in vivo pharmacological characterization of human PNPLA3-targeting short interfering RNA molecules for the treatment of metabolic dysfunction-associated steatohepatitis
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Song, Jieun;
Deval, Jerome;
Adame, Lillian;
Jaisinghani, Ruchika;
Tso, Emily;
Lin, Daniel;
Bhattacharya, Aneerban;
Stoycheva, Antitsa;
Sousa, Jacquelyn;
Parish, Craig;
Montero, Saul Martinez;
Rajwanshi, Vivek;
Daguison, Shane;
Gohil, Vikrant;
Zhang, Qingling;
Williamson, Toni;
Chanda, Sushmita;
Talukdar, Saswata;
Smith, David;
Beigelman, Leonid;
Symons, Julian;
Zhou, Yingjiang;
Luong, Xuan;
;
(Journal of hepatology : the journal of the European Association for the Study of the Liver,
v.80,
2024,
pp.S564-S565)
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105
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FRI-257 Next generation hepatitis B virus antisense oligonucleotides incorporating novel chemistries demonstrated significantly improved properties compared to current clinical candidates
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Hong, Jin;
Rajwanshi, Vivek;
Lu, Jimmy;
Luo, Min;
Kang, Hyunsoon;
Passow, Kellan;
Sousa, Jacquelyn;
Cho, Dana;
Cortez, John;
Song, Jieun;
Adame, Lillian;
Liu, Cheng;
Stevens, Sarah;
Misner, Dinah;
Daguison, Shane;
Gupta, Kusum;
Bhattacharya, Aneerban;
Stoycheva, Antitsa;
Ahmed-Belkacem, Rostom;
Luong, Xuan;
Blatt, Lawrence;
Sun, Li;
Smith, David;
Symons, Julian;
;
(Journal of hepatology : the journal of the European Association for the Study of the Liver,
v.82,
2025,
pp.S763)
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106
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An in vivo duck hepatitis B virus model recapitulates key aspects of nucleic acid polymer treatment outcomes in chronic hepatitis B patients
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Debing, Yannick;
Vanrusselt, Hannah;
Degrauwe, Lars;
de Oliveira, Daniel Apolô
nio Silva;
Kariuki, Christopher;
Ebwanga, Ebanja Joseph;
Bashir, Shahbaz;
Merckx, Wouter;
Thatikonda, Santhosh;
Gohil, Vikrant;
Smith, David;
Raboisson, Pierre;
Montero, Saul;
Hong, Jin;
Sanchez, Abel Acosta;
Blatt, Lawrence;
Symons, Julian;
Lin, Tse-I;
Beigelman, Leonid;
Paeshuyse, Jan;
;
(Journal of hepatology : the journal of the European Association for the Study of the Liver,
v.78,
2023,
pp.S1051)
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107
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Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)
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Luong Xuan G.;
Stevens Sarah K.;
Jekle Andreas;
Lin Tse-I;
Gupta Kusum;
Misner Dinah;
Chanda Sushmita;
Mukherjee Sucheta;
Williams Caroline;
Stoycheva Antitsa;
Blatt Lawrence M.;
Beigelman Leonid N.;
Symons Julian A.;
Raboisson Pierre;
McGowan David;
Vandyck Koen;
Deval Jerome;
;
(,
v.,
2020,
)
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108
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The Novel Nucleoside Analog R1479 (4′-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture
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Klumpp, Klaus;
Lé
vê
que, Vincent;
Le Pogam, Sophie;
Ma, Han;
Jiang, Wen-Rong;
Kang, Hyunsoon;
Granycome, Caroline;
Singer, Margaret;
Laxton, Carl;
Hang, Julie Qi;
Sarma, Keshab;
Smith, David B.;
Heindl, Dieter;
Hobbs, Chris J.;
Merrett, John H.;
Symons, Julian;
Cammack, Nick;
Martin, Joseph A.;
Devos, Rene;
Ná
jera, Isabel;
;
(The Journal of biological chemistry,
v.281,
2006,
pp.3793-3799)
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109
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Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH
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Vandyck, Koen;
McGowan, David C.;
Luong, Xuan G.;
Stevens, Sarah K.;
Jekle, Andreas;
Gupta, Kusum;
Misner, Dinah L.;
Chanda, Sushmita;
Serebryany, Vladimir;
Welch, Michael;
Hu, Haiyang;
Lv, Zhidan;
Williams, Caroline;
Maskos, Klaus;
Lammens, Alfred;
Stoycheva, Antitsa D.;
Lin, Tse-I;
Blatt, Lawrence M.;
Beigelman, Leonid N.;
Symons, Julian A.;
Raboisson, Pierre;
Deval, Jerome;
Aligos Belgium BV , Gaston Geenslaan 1 , 3001 Leuven , Belgium;
Aligos Therapeutics, Incorporated , 1 Corporate Drive , South San Francisco , California 94080 , United States;
Aligos Therapeutics, Incorporated , 1 Corporate Drive , South San Francisco , California 94080 , United States;
Aligos Therapeutics, Incorporated , 1 Corporate Drive , South San Francisco , California 94080 , United States;
Aligos Therapeutics, Incorporated , 1 Corporate Drive , South San Francisco , California 94080 , United States;
Aligos Therapeutics, Incorporated , 1 Corporate Drive , South San Francisco , California 94080 , United States;
Aligos Therapeutics, Incorporated , 1 Corporate Drive , South San Francisco , California 94080 , United States;
Aligos Therapeutics, Inco;
(Journal of medicinal chemistry,
v.67,
2024,
pp.14840-14851)
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110
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ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model
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Vandyck, Koen;
Abdelnabi, Rana;
Gupta, Kusum;
Jochmans, Dirk;
Jekle, Andreas;
Deval, Jerome;
Misner, Dinah;
Bardiot, Dorothé
e;
Foo, Caroline S.;
Liu, Cheng;
Ren, Suping;
Beigelman, Leonid;
Blatt, Lawrence M.;
Boland, Sandro;
Vangeel, Laura;
Dejonghe, Steven;
Chaltin, Patrick;
Marchand, Arnaud;
Serebryany, Vladimir;
Stoycheva, Antitsa;
Chanda, Sushmita;
Symons, Julian A.;
Raboisson, Pierre;
Neyts, Johan;
Aligos Belgium BV;
Rega Institute for Medical Research, KU Leuven;
Aligos Therapeutics, Inc.;
Rega Institute for Medical Research, KU Leuven;
Aligos Therapeutics, Inc.;
Aligos Therapeutics, Inc.;
Aligos Therapeutics, Inc.;
CISTIM Leuven vzw;
Rega Institute for Medical Research, KU Leuven;
Aligos Therapeutics, Inc.;
Aligos Therapeutics, Inc.;
Aligos Belgium BV;
Aligos Belgium BV;
CISTIM Leuven vzw;
Rega Institute for Medical Research, KU Leuven;
Rega Institute for Medical Research, KU Leuven;
Centre for Drug Design and Discovery (CD3), KU Leuven Belgium